For efficacious delivery of medications in asthma and chronic obstructive pulmonary disease (COPD), compliance with the correct use of the medication delivery device is just as important as medication adherence. When selecting a medication delivery system, it is important that healthcare professionals not only consider the drug but also understand the aerosol delivery system and match it to the individual patient’s needs and abilities. This presentation will discuss these issues and key steps to match the device to the patient in order to overcome device delirium and optimize medication delivery outcomes.